'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Published

Journal Article

T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we identify a homeostatic mechanism that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR). 'Coreceptor tuning' results from interplay between cytokine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 expression and thereby promote TCR engagement of self ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrease CD8 expression. This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity.

Full Text

Duke Authors

Cited Authors

  • Park, J-H; Adoro, S; Lucas, PJ; Sarafova, SD; Alag, AS; Doan, LL; Erman, B; Liu, X; Ellmeier, W; Bosselut, R; Feigenbaum, L; Singer, A

Published Date

  • October 2007

Published In

Volume / Issue

  • 8 / 10

Start / End Page

  • 1049 - 1059

PubMed ID

  • 17873878

Pubmed Central ID

  • 17873878

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1512

Language

  • eng