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Control of CD4 gene expression: connecting signals to outcomes in T cell development.

Publication ,  Journal Article
Sarafova, SD; Siu, G
Published in: Braz J Med Biol Res
July 1999

The control of CD4 gene expression is essential for proper T lymphocyte development. Signals transmitted from the T-cell antigen receptor (TCR) during the thymic selection processes are believed to be linked to the regulation of CD4 gene expression during specific stages of T cell development. Thus, a study of the factors that control CD4 gene expression may lead to further insight into the molecular mechanisms that drive thymic selection. In this review, we discuss the work conducted to date to identify and characterize the cis-acting transcriptional control elements in the CD4 locus and the DNA-binding factors that mediate their function. From these studies, it is becoming clear that the molecular mechanisms controlling CD4 gene expression are very complex and differ at each stage of development. Thus, the control of CD4 expression is subject to many different influences as the thymocyte develops.

Duke Scholars

Published In

Braz J Med Biol Res

DOI

ISSN

0100-879X

Publication Date

July 1999

Volume

32

Issue

7

Start / End Page

785 / 803

Location

Brazil

Related Subject Headings

  • T-Lymphocytes
  • Promoter Regions, Genetic
  • Neurology & Neurosurgery
  • Mice
  • Genes, Regulator
  • Gene Expression
  • Cell Differentiation
  • CD4 Antigens
  • Animals
  • 32 Biomedical and clinical sciences
 

Citation

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Sarafova, S. D., & Siu, G. (1999). Control of CD4 gene expression: connecting signals to outcomes in T cell development. Braz J Med Biol Res, 32(7), 785–803. https://doi.org/10.1590/s0100-879x1999000700001
Sarafova, S. D., and G. Siu. “Control of CD4 gene expression: connecting signals to outcomes in T cell development.Braz J Med Biol Res 32, no. 7 (July 1999): 785–803. https://doi.org/10.1590/s0100-879x1999000700001.
Sarafova SD, Siu G. Control of CD4 gene expression: connecting signals to outcomes in T cell development. Braz J Med Biol Res. 1999 Jul;32(7):785–803.
Sarafova, S. D., and G. Siu. “Control of CD4 gene expression: connecting signals to outcomes in T cell development.Braz J Med Biol Res, vol. 32, no. 7, July 1999, pp. 785–803. Pubmed, doi:10.1590/s0100-879x1999000700001.
Sarafova SD, Siu G. Control of CD4 gene expression: connecting signals to outcomes in T cell development. Braz J Med Biol Res. 1999 Jul;32(7):785–803.

Published In

Braz J Med Biol Res

DOI

ISSN

0100-879X

Publication Date

July 1999

Volume

32

Issue

7

Start / End Page

785 / 803

Location

Brazil

Related Subject Headings

  • T-Lymphocytes
  • Promoter Regions, Genetic
  • Neurology & Neurosurgery
  • Mice
  • Genes, Regulator
  • Gene Expression
  • Cell Differentiation
  • CD4 Antigens
  • Animals
  • 32 Biomedical and clinical sciences