Computer programs for the concordance correlation coefficient.


Journal Article

The CCC macro is presented for computation of the concordance correlation coefficient (CCC), a common measure of reproducibility. The macro has been produced in both SAS and R, and a detailed presentation of the macro input and output for the SAS program is included. The macro provides estimation of three versions of the CCC, as presented by Lin [L.I.-K. Lin, A concordance correlation coefficient to evaluate reproducibility, Biometrics 45 (1989) 255-268], Barnhart et al. [H.X. Barnhart, J.L. Haber, J.L. Song, Overall concordance correlation coefficient for evaluating agreement among multiple observers, Biometrics 58 (2002) 1020-1027], and Williamson et al. [J.M. Williamson, S.B. Crawford, H.M. Lin, Resampling dependent concordance correlation coefficients, J. Biopharm. Stat. 17 (2007) 685-696]. It also provides bootstrap confidence intervals for the CCC, as well as for the difference in CCCs for both independent and dependent samples. The macro is designed for balanced data only. Detailed explanation of the involved computations and macro variable definitions are provided in the text. Two biomedical examples are included to illustrate that the macro can be easily implemented.

Full Text

Duke Authors

Cited Authors

  • Crawford, SB; Kosinski, AS; Lin, H-M; Williamson, JM; Barnhart, HX

Published Date

  • October 2007

Published In

Volume / Issue

  • 88 / 1

Start / End Page

  • 62 - 74

PubMed ID

  • 17709153

Pubmed Central ID

  • 17709153

International Standard Serial Number (ISSN)

  • 0169-2607

Digital Object Identifier (DOI)

  • 10.1016/j.cmpb.2007.07.003


  • eng

Conference Location

  • Ireland