Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.
(Journal Article;Multicenter Study)
We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.
McGovern, PG; Carson, SA; Barnhart, HX; Myers, ER; Legro, RS; Diamond, MP; Carr, BR; Schlaff, WD; Coutifaris, C; Cataldo, NA; Steinkampf, MP; Nestler, JE; Gosman, G; Leppert, PC; Giudice, LC; National Institute of Child Health and Human Development-Reproductive Medicine Network,
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