Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.

Journal Article (Journal Article;Multicenter Study)

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin dosing was not the reason for low ovulation and pregnancy rates in the PPCOS Trial.

Full Text

Duke Authors

Cited Authors

  • McGovern, PG; Carson, SA; Barnhart, HX; Myers, ER; Legro, RS; Diamond, MP; Carr, BR; Schlaff, WD; Coutifaris, C; Cataldo, NA; Steinkampf, MP; Nestler, JE; Gosman, G; Leppert, PC; Giudice, LC; National Institute of Child Health and Human Development-Reproductive Medicine Network,

Published Date

  • October 2008

Published In

Volume / Issue

  • 90 / 4

Start / End Page

  • 1283 - 1286

PubMed ID

  • 18082737

Pubmed Central ID

  • PMC2570771

Electronic International Standard Serial Number (EISSN)

  • 1556-5653

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2007.09.004

Language

  • eng

Conference Location

  • United States