C-nitroso donors of nitric oxide.

Journal Article (Journal Article)

A complete understanding of the biological activity of nitric oxide (NO) is complicated by the different reactivity profiles of its various species and by the often complex decomposition behavior of the NO progenitors in common use. Here, we report that appropriately substituted C-nitroso compounds act solely as donors of neutral nitric oxide through a first-order homolytic C-N bond scission to release up to 88% nitric oxide in DMSO at 25 degrees C. The reaction produces a carbon radical, and the yield of nitric oxide is dependent on the availability of radical traps. C-Nitroso compounds are sources of biologically active neutral NO and display potent NO bioactivity in a rabbit aortic ring assay.

Full Text

Duke Authors

Cited Authors

  • Chakrapani, H; Bartberger, MD; Toone, EJ

Published Date

  • February 2009

Published In

Volume / Issue

  • 74 / 4

Start / End Page

  • 1450 - 1453

PubMed ID

  • 19146387

Electronic International Standard Serial Number (EISSN)

  • 1520-6904

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo802517t


  • eng