The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth.

Journal Article (Academic article)

BACKGROUND: In plants, the phytohormone auxin is a crucial regulator sustaining growth and development. At the cellular level, auxin is interpreted differentially in a tissue- and dose-dependent manner. Mechanisms of auxin signalling are partially unknown and the contribution of the AUXIN BINDING PROTEIN 1 (ABP1) as an auxin receptor is still a matter of debate. METHODOLOGY/PRINCIPAL FINDINGS: Here we took advantage of the present knowledge of the root biological system to demonstrate that ABP1 is required for auxin response. The use of conditional ABP1 defective plants reveals that the protein is essential for maintenance of the root meristem and acts at least on the D-type CYCLIN/RETINOBLASTOMA pathway to control entry into the cell cycle. ABP1 affects PLETHORA gradients and confers auxin sensitivity to root cells thus defining the competence of the cells to be maintained within the meristem or to elongate. ABP1 is also implicated in the regulation of gene expression in response to auxin. CONCLUSIONS/SIGNIFICANCE: Our data support that ABP1 is a key regulator for root growth and is required for auxin-mediated responses. Differential effects of ABP1 on various auxin responses support a model in which ABP1 is the major regulator for auxin action on the cell cycle and regulates auxin-mediated gene expression and cell elongation in addition to the already well known TIR1-mediated ubiquitination pathway.

Full Text

Duke Authors

Cited Authors

  • Tromas, A; Braun, N; Muller, P; Khodus, T; Paponov, IA; Palme, K; Ljung, K; Lee, JY; Benfey, P; Murray, JA; Scheres, B; Perrot Rechenmann, C

Published Date

  • September 2009

Published In

Volume / Issue

  • 4 / 9

Start / End Page

  • e6648 -

PubMed ID

  • 19777056

Pubmed Central ID

  • PMC2744284

International Standard Serial Number (ISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0006648


  • English

Conference Location

  • united states