Modafinil and cocaine interactions.


Journal Article

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.

Full Text

Cited Authors

  • Malcolm, R; Swayngim, K; Donovan, JL; DeVane, CL; Elkashef, A; Chiang, N; Khan, R; Mojsiak, J; Myrick, DL; Hedden, S; Cochran, K; Woolson, RF

Published Date

  • January 2006

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 577 - 587

PubMed ID

  • 17127546

Pubmed Central ID

  • 17127546

Electronic International Standard Serial Number (EISSN)

  • 1097-9891

International Standard Serial Number (ISSN)

  • 0095-2990

Digital Object Identifier (DOI)

  • 10.1080/00952990600920425


  • eng