Effect of psyllium fiber supplementation on C-reactive protein: the trial to reduce inflammatory markers (TRIM).


Journal Article

Recent evidence supports a significant association between the intake of dietary fiber and levels of inflammatory markers. The objective of this study was to determine whether daily fiber supplementation would reduce levels of inflammatory markers.This study was a prospective randomized controlled trial at a single university medical center. Participants were overweight or obese adults with no history of heart disease. The intervention was psyllium supplementation at either 7 or 14 g/d for 3 months compared with no supplements in a control group. The main outcome measure was change in level of high-sensitivity C-reactive protein (hsCRP) concentration; secondary outcomes included changes in interleukin-6 (IL-6) levels, fibrinogen levels, and white blood cell (WBC) count. Protocol completers attended at least 2 visits and took more than 75% of the prescribed fiber dose.In this intent-to-treat analysis (n = 158), there were no significant differences between either of the 2 treatment groups and the control group in the amount of change in CRP, fibrinogen, or IL-6 levels or in WBC count (P>.05). In the analysis of protocol completers (n = 132), there also were no significant differences between the groups except for a small decrease in fibrinogen level in the high-fiber group (-6 mg/dL [-0.18 micromol/L] compared with 13 mg/dL [0.38 micromol/L] in the control group, P<.05).Psyllium fiber supplementation did not significantly reduce CRP levels in overweight or obese individuals in this trial, and changes in other markers were not consistent. Further research is needed to determine whether other fibers or nutrients can reduce inflammatory markers.

Full Text

Cited Authors

  • King, DE; Mainous, AG; Egan, BM; Woolson, RF; Geesey, ME

Published Date

  • March 2008

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 100 - 106

PubMed ID

  • 18332401

Pubmed Central ID

  • 18332401

Electronic International Standard Serial Number (EISSN)

  • 1544-1717

International Standard Serial Number (ISSN)

  • 1544-1709

Digital Object Identifier (DOI)

  • 10.1370/afm.819


  • eng