Preview of a new trial of extracranial-to-intracranial arterial anastomosis: the carotid occlusion surgery study.


Journal Article

In 1985, the International Study of Extracranial-to-Intracranial Arterial Anastomosis demonstrated no benefit from extracranial-to-intracranial arterial bypass operations in treatment of patients with extensive cerebrovascular disease including those with occlusions of the internal carotid artery. Interest in the potential use of extracranial-to-intracranial arterial bypass operations, however, has been rekindled by evidence that some patients with occlusion of the internal carotid artery have a poor collateral circulation and a high risk for recurrent ischemic events. Other patients with adequate perfusion after occlusion have a low likelihood for recurrent stroke. Restricting surgical treatment to only those patients judged to have a high risk for recurrent stroke might improve the usefulness of the bypass operation. A new clinical trial is proposed, testing the potential usefulness of extracranial-to-intracranial arterial bypass operations for treatment of carefully selected patients with occlusion of the internal carotid artery. Several issues that are being addressed in this new trial are described in this article.

Full Text

Cited Authors

  • Adams, HP; Powers, WJ; Grubb, RL; Clarke, WR; Woolson, RF

Published Date

  • July 2001

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 613 - x

PubMed ID

  • 11390318

Pubmed Central ID

  • 11390318

Electronic International Standard Serial Number (EISSN)

  • 1558-1349

International Standard Serial Number (ISSN)

  • 1042-3680

Digital Object Identifier (DOI)

  • 10.1016/s1042-3680(18)30047-0


  • eng