Dietary magnesium and C-reactive protein levels.


Journal Article

OBJECTIVE:Current dietary guidelines recommend adequate intake of magnesium (310-420 mg daily) in order to maintain health and lower the risk of cardiovascular disease. Recent evidence from animal and clinical studies suggests that magnesium may be associated with inflammatory processes. The objective of this study was to determine whether dietary magnesium consumption is associated with C-reactive protein (CRP), a marker of inflammation, in a nationally representative sample. METHODS:Analysis of adult (> or =17 years) participants in a cross-sectional nationally representative survey (National Health and Nutrition Examination Survey 1999-2000 [NHANES]) who were not taking magnesium or magnesium-containing supplements. The primary outcome measure was high sensitivity CRP (elevated > or =3.0 mg/L). RESULTS:Among US adults, 68% consumed less than the recommended daily allowance (RDA) of magnesium, and 19% consumed less than 50% of the RDA. After controlling for demographic and cardiovascular risk factors, adults who consumed or =RDA (Odds Ratio [OR] for intake <50% RDA = 1.75, 95% Confidence Interval [CI] 1.08-2.87). Adults who were over age 40 with a BMI >25 and who consumed <50% RDA for magnesium were 2.24 times more likely to have elevated CRP (95% CI 1.13-4.46) than adults > or =RDA. CONCLUSIONS:Most Americans consume magnesium at levels below the RDA. Individuals with intakes below the RDA are more likely to have elevated CRP, which may contribute to cardiovascular disease risk.

Full Text

Cited Authors

  • King, DE; Mainous, AG; Geesey, ME; Woolson, RF

Published Date

  • June 2005

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 166 - 171

PubMed ID

  • 15930481

Pubmed Central ID

  • 15930481

Electronic International Standard Serial Number (EISSN)

  • 1541-1087

International Standard Serial Number (ISSN)

  • 0731-5724

Digital Object Identifier (DOI)

  • 10.1080/07315724.2005.10719461


  • eng