Relationship between depression and pancreatic cancer in the general population.
OBJECTIVE:Prior research suggesting a relationship between pancreatic cancer and depression conducted on clinical populations has been subject to recall bias. We reexamined this association using longitudinal population-based data. METHODS:This was a retrospective cohort study using longitudinal insurance claims data. RESULTS:Men with mental disorders were more likely to develop pancreatic cancer than those without psychiatric claims (odds ratio 2.4, confidence interval 1.15-4.78). Depression more commonly preceded pancreatic cancer than it did other gastrointestinal malignancies (odds ratio 4.6, confidence interval 1.07-19.4) or all other cancers (odds ratio 4.1, confidence interval 1.05-16.0). CONCLUSIONS:Depression and pancreatic cancer are associated in the general population.
Carney, CP; Jones, L; Woolson, RF; Noyes, R; Doebbeling, BN
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