Antimicrobial resistance trends and outbreak frequency in United States hospitals.

Journal Article

We assessed resistance rates and trends for important antimicrobial-resistant pathogens (oxacillin-resistant Staphylococcus aureus [ORSA], vancomycin-resistant Enterococcus species [VRE], ceftazidime-resistant Klebsiella species [K-ESBL], and ciprofloxacin-resistant Escherichia coli [QREC]), the frequency of outbreaks of infection with these resistant pathogens, and the measures taken to control resistance in a stratified national sample of 670 hospitals. Four hundred ninety-four (74%) of 670 surveys were returned. Resistance rates were highest for ORSA (36%), followed by VRE (10%), QREC (6%), and K-ESBL (5%). Two-thirds of hospitals reported increasing ORSA rates, whereas only 4% reported decreasing rates, and 24% reported ORSA outbreaks within the previous year. Most hospitals (87%) reported having implemented measures to rapidly detect resistance, but only approximately 50% reported having provided appropriate resources for antimicrobial resistance prevention (53%) or having implemented antimicrobial use guidelines (60%). The most common resistant pathogen in US hospitals is ORSA, which accounts for many recognized outbreaks and is increasing in frequency in most facilities. Current practices to prevent and control antimicrobial resistance are inadequate.

Full Text

Duke Authors

Cited Authors

  • Diekema, DJ; BootsMiller, BJ; Vaughn, TE; Woolson, RF; Yankey, JW; Ernst, EJ; Flach, SD; Ward, MM; Franciscus, CLJ; Pfaller, MA; Doebbeling, BN

Published Date

  • January 1, 2004

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 78 - 85

PubMed ID

  • 14679451

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/380457

Language

  • eng

Conference Location

  • United States