Viral induced fusion and syncytium formation: measurement by the Kolmogorov-Smirnov statistical test.


Journal Article

Fusion and syncytium formation induced by the expression of fusogenic viral glycoproteins are common cytopathic effects. Numerous laboratories have studied mechanisms of fusion, generally with each laboratory utilizing a different method to measure polykaryote formation. There is little consensus as to which methods are preferred for measuring and comparing fusion. The Kolmogorov-Smirnov two-sample test was used to document a statistical difference in syncytium formation between two forms of a varicella-zoster virus (VZV) fusogenic glycoprotein. This test is widely applied toward the analysis of large human populations in which interest centers on testing the hypothesis that the distributions of two sub-populations are identical. We suggest that the Kolmogorov-Smirnov test is a preferable method to assess whether differences in distribution of syncytia size between two fusogenic glycoproteins are meaningful statistically.

Full Text

Cited Authors

  • Pasieka, TJ; Woolson, RF; Grose, C

Published Date

  • August 2003

Published In

Volume / Issue

  • 111 / 2

Start / End Page

  • 157 - 161

PubMed ID

  • 12880931

Pubmed Central ID

  • 12880931

Electronic International Standard Serial Number (EISSN)

  • 1879-0984

International Standard Serial Number (ISSN)

  • 0166-0934

Digital Object Identifier (DOI)

  • 10.1016/s0166-0934(03)00152-6


  • eng