Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas.

Journal Article (Journal Article)

Tumour oxygenation was measured in seven canine soft tissue sarcomas being treated with a fractionated course of radiation and hyperthermia. Measurements obtained during treatment were compared to pre-treatment measurements. The most important finding was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment. This is an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. In other tumours, potentially less advantageous changes in oxygenation may be hyperthermia fractionation related and this deserves further investigation.

Full Text

Duke Authors

Cited Authors

  • Thrall, DE; Larue, SM; Pruitt, AF; Case, B; Dewhirst, MW

Published Date

  • August 2006

Published In

Volume / Issue

  • 22 / 5

Start / End Page

  • 365 - 373

PubMed ID

  • 16891239

International Standard Serial Number (ISSN)

  • 0265-6736

Digital Object Identifier (DOI)

  • 10.1080/02656730600836386


  • eng

Conference Location

  • England