Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas.
Journal Article (Journal Article)
Tumour oxygenation was measured in seven canine soft tissue sarcomas being treated with a fractionated course of radiation and hyperthermia. Measurements obtained during treatment were compared to pre-treatment measurements. The most important finding was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment. This is an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. In other tumours, potentially less advantageous changes in oxygenation may be hyperthermia fractionation related and this deserves further investigation.
Full Text
Duke Authors
Cited Authors
- Thrall, DE; Larue, SM; Pruitt, AF; Case, B; Dewhirst, MW
Published Date
- August 2006
Published In
Volume / Issue
- 22 / 5
Start / End Page
- 365 - 373
PubMed ID
- 16891239
International Standard Serial Number (ISSN)
- 0265-6736
Digital Object Identifier (DOI)
- 10.1080/02656730600836386
Language
- eng
Conference Location
- England