Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.

Journal Article (Journal Article)

We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (rho=0.89, p=9x10(-6), N=15) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (rho=0.56, p=0.03, N=15).

Full Text

Duke Authors

Cited Authors

  • Skala, MC; Fontanella, A; Hendargo, H; Dewhirst, MW; Izatt, JA

Published Date

  • February 1, 2009

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 289 - 291

PubMed ID

  • 19183634

Pubmed Central ID

  • PMC2715151

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.34.000289


  • eng

Conference Location

  • United States