One-stop-shop tumor imaging: buy hypoxia, get lactate free.

Journal Article

The ability to noninvasively assess physiological changes in solid tumors is desired for its diagnostic and therapeutic potential. In this issue of JCI, Matsumoto and colleagues reveal their development and use of a novel imaging approach, combining pulsed electron paramagnetic resonance imaging (EPRI) with conventional MRI to image squamous cell carcinoma tumor-bearing mice (See the related article beginning on page 1965). This method provides coregistered images of oxygenation and blood volume/flow with the underlying anatomy and concentrations of metabolites such as lactate and choline. This technique, combining functional and anatomic imaging, shows immediate preclinical applicability in monitoring factors that control tumor hypoxia and metabolism and may have future clinical potential for monitoring tumor response to treatment.

Full Text

Duke Authors

Cited Authors

  • Manzoor, AA; Schroeder, T; Dewhirst, MW

Published Date

  • May 2008

Published In

Volume / Issue

  • 118 / 5

Start / End Page

  • 1616 - 1619

PubMed ID

  • 18431517

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI35543

Language

  • eng

Conference Location

  • United States