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Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.

Publication ,  Journal Article
Anscher, MS; Chen, L; Rabbani, Z; Kang, S; Larrier, N; Huang, H; Samulski, TV; Dewhirst, MW; Brizel, DM; Folz, RJ; Vujaskovic, Z
Published in: Int J Radiat Oncol Biol Phys
May 1, 2005

The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve this goal, a thorough understanding of the molecular mechanisms responsible for radiation-induced toxicity will be essential. Recent research has demonstrated that ionizing radiation triggers a series of genetic and molecular events, which might lead to chronic persistent alterations in the microenvironment and an aberrant wound-healing response. Disrupted epithelial-stromal cell communication might also be important. With the application of a better understanding of fundamental biology to clinical practice, new approaches to treating and preventing normal tissue injury can focus on correcting these disturbed molecular processes.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

May 1, 2005

Volume

62

Issue

1

Start / End Page

255 / 259

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Superoxide Dismutase
  • Reactive Oxygen Species
  • Radiation Tolerance
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Endothelium, Vascular
  • Cytokines
 

Citation

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ICMJE
MLA
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Anscher, M. S., Chen, L., Rabbani, Z., Kang, S., Larrier, N., Huang, H., … Vujaskovic, Z. (2005). Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys, 62(1), 255–259. https://doi.org/10.1016/j.ijrobp.2005.01.040
Anscher, Mitchell S., Liguang Chen, Zahid Rabbani, Song Kang, Nicole Larrier, Hong Huang, Thaddeus V. Samulski, et al. “Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.Int J Radiat Oncol Biol Phys 62, no. 1 (May 1, 2005): 255–59. https://doi.org/10.1016/j.ijrobp.2005.01.040.
Anscher MS, Chen L, Rabbani Z, Kang S, Larrier N, Huang H, et al. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):255–9.
Anscher, Mitchell S., et al. “Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.Int J Radiat Oncol Biol Phys, vol. 62, no. 1, May 2005, pp. 255–59. Pubmed, doi:10.1016/j.ijrobp.2005.01.040.
Anscher MS, Chen L, Rabbani Z, Kang S, Larrier N, Huang H, Samulski TV, Dewhirst MW, Brizel DM, Folz RJ, Vujaskovic Z. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):255–259.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

May 1, 2005

Volume

62

Issue

1

Start / End Page

255 / 259

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Superoxide Dismutase
  • Reactive Oxygen Species
  • Radiation Tolerance
  • Radiation Injuries
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Endothelium, Vascular
  • Cytokines