Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.
Journal Article (Journal Article;Review)
The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.
- Tashjian, JA; Dewhirst, MW; Needham, D; Viglianti, BL
- February 2008
- International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Volume / Issue
- 24 / 1
Start / End Page
- 79 - 90
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)