HIF-1 and tumour radiosensitivity.


Journal Article (Review)

Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.

Full Text

Duke Authors

Cited Authors

  • Moeller, BJ; Dewhirst, MW

Published Date

  • July 3, 2006

Published In

Volume / Issue

  • 95 / 1

Start / End Page

  • 1 - 5

PubMed ID

  • 16735998

Pubmed Central ID

  • 16735998

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6603201


  • eng

Conference Location

  • England