Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.

Journal Article (Review)

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay between free radicals, hypoxia and HIF1 activity is complex and can influence the earliest stages of tumour development. The hypoxic environment of tumours is heterogeneous, both spatially and temporally, and can change in response to cytotoxic therapy. Free radicals created by hypoxia, hypoxia-reoxygenation cycling and immune cell infiltration after cytotoxic therapy strongly influence HIF1 activity. HIF1 can then promote endothelial and tumour cell survival. As discussed here, a constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit.

Full Text

Duke Authors

Cited Authors

  • Dewhirst, MW; Cao, Y; Moeller, B

Published Date

  • June 2008

Published In

Volume / Issue

  • 8 / 6

Start / End Page

  • 425 - 437

PubMed ID

  • 18500244

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/nrc2397

Language

  • eng

Conference Location

  • England