Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.


Journal Article (Review)

The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.

Full Text

Duke Authors

Cited Authors

  • Dewhirst, MW; Cao, Y; Li, CY; Moeller, B

Published Date

  • June 2007

Published In

Volume / Issue

  • 83 / 3

Start / End Page

  • 249 - 255

PubMed ID

  • 17560674

Pubmed Central ID

  • 17560674

International Standard Serial Number (ISSN)

  • 0167-8140

Digital Object Identifier (DOI)

  • 10.1016/j.radonc.2007.05.016


  • eng

Conference Location

  • Ireland