Interstitial hyperthermia and iridium brachytherapy in treatment of malignant glioma. A phase I clinical trial.


Journal Article

An oncolytic effect of hyperthermia in the 42 degrees to 43 degrees C range has been previously demonstrated in cell culture and animal models. To apply this modality clinically, an interstitial microwave antenna array system has been developed for the delivery of controlled hyperthermia to an intracranial tumor volume, and a Phase I clinical trial involving six patients with malignant gliomas was undertaken. The protocol to study technical feasibility and patient tolerance combined interstitial iridium-192 irradiation and interstitial hyperthermia with 60-minute hyperthermia sessions immediately before and after brachytherapy. After-loading catheters suitable for both treatment modalities were implanted using a computerized tomography-assisted technique. Thermometry data confirmed the ability of a microwave antenna system to achieve reliable temperature distributions, and reasonable patient tolerance was documented.

Full Text

Duke Authors

Cited Authors

  • Roberts, DW; Coughlin, CT; Wong, TZ; Fratkin, JD; Douple, EB; Strohbehn, JW

Published Date

  • April 1986

Published In

Volume / Issue

  • 64 / 4

Start / End Page

  • 581 - 587

PubMed ID

  • 3512798

Pubmed Central ID

  • 3512798

International Standard Serial Number (ISSN)

  • 0022-3085

Digital Object Identifier (DOI)

  • 10.3171/jns.1986.64.4.0581


  • eng

Conference Location

  • United States