Intraoperative interstitial microwave-induced hyperthermia and brachytherapy.

Journal Article

Intra-operative placement of 11-gauge nylon catheters into deep-seated unresectable tumors for interstitial brachytherapy permits localized heating of tumors (hyperthermia) using microwave (915 MHz) antennas which are inserted into these catheters. Four preliminary cases are described where epithelial tumors at various sites were implanted with an antenna array and heated for 1 hour, both before and after the iridium-192 brachytherapy. Temperatures were monitored in catheters required for the appropriate radiation dosimetry but not required for the interstitial microwave antenna array hyperthermia (IMAAH) system. Additional thermometry was obtained using nonperturbed fiberoptic thermometry probes inserted into the catheters' housing antennas. No significant complications, such as bleeding or infection, were observed. This approach to cancer therapy is shown to be feasible and it produces controlled, localized hyperthermia, with temperatures of 50 degrees C or more in tumors. This technique may offer a therapeutic option for pelvic, intra-abdominal and head and neck tumors.

Full Text

Duke Authors

Cited Authors

  • Coughlin, CT; Wong, TZ; Strohbehn, JW; Colacchio, TA; Sutton, JE; Belch, RZ; Douple, EB

Published Date

  • September 1985

Published In

Volume / Issue

  • 11 / 9

Start / End Page

  • 1673 - 1678

PubMed ID

  • 4030435

International Standard Serial Number (ISSN)

  • 0360-3016

Language

  • eng

Conference Location

  • United States