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Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy.

Publication ,  Journal Article
Schwartz, RB; Hsu, L; Kacher, DF; Wong, TZ; Alexander, E; Okon, S; Guttmann, CR; Black, PM; Kelley, RA; Moriarty, T; Martin, C; Isbister, HG ...
Published in: J Magn Reson Imaging
1998

In patients with malignant astrocytomas or metastatic brain disease treated with high-dose radiotherapy, conventional imaging methods may not adequately distinguish recurrent tumor from radiation change. We used a fast spoiled gradient refocusing technique in the open-configuration intraoperative MR system to assess the rate of regional enhancement of the treated tumor bed and to localize specific sites for pathologic sampling to determine whether gadolinium uptake correlated with histologic data. Twenty-four patients were studied. Fourteen of 15 patients with areas of early enhancement had recurrent tumor present in histologic samples, and 8 of the remaining 9 patients had only reactive changes. Dynamic MRI was predictive of recurrent tumor (P < .0005, Fisher exact test and P < .002, Student t test). We conclude that dynamic MRI in the open-bore magnet is a promising method for localizing potential sites of active tumor growth in patients treated for malignant astrocytomas and metastatic brain lesions.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1998

Volume

8

Issue

5

Start / End Page

1085 / 1089

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Radiotherapy, High-Energy
  • Radiosurgery
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Intraoperative Care
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schwartz, R. B., Hsu, L., Kacher, D. F., Wong, T. Z., Alexander, E., Okon, S., … Jolesz, F. A. (1998). Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy. J Magn Reson Imaging, 8(5), 1085–1089. https://doi.org/10.1002/jmri.1880080513
Schwartz, R. B., L. Hsu, D. F. Kacher, T. Z. Wong, E. Alexander, S. Okon, C. R. Guttmann, et al. “Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy.J Magn Reson Imaging 8, no. 5 (1998): 1085–89. https://doi.org/10.1002/jmri.1880080513.
Schwartz RB, Hsu L, Kacher DF, Wong TZ, Alexander E, Okon S, et al. Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy. J Magn Reson Imaging. 1998;8(5):1085–9.
Schwartz, R. B., et al. “Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy.J Magn Reson Imaging, vol. 8, no. 5, 1998, pp. 1085–89. Pubmed, doi:10.1002/jmri.1880080513.
Schwartz RB, Hsu L, Kacher DF, Wong TZ, Alexander E, Okon S, Guttmann CR, Black PM, Kelley RA, Moriarty T, Martin C, Isbister HG, Cahill CD, Spaulding SA, Jolesz FA. Intraoperative dynamic MRI: localization of sites of brain tumor recurrence after high-dose radiotherapy. J Magn Reson Imaging. 1998;8(5):1085–1089.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1998

Volume

8

Issue

5

Start / End Page

1085 / 1089

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Radiotherapy, High-Energy
  • Radiosurgery
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Intraoperative Care
  • Humans