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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.

Publication ,  Journal Article
Ebert, PJR; Jiang, S; Xie, J; Li, Q-J; Davis, MM
Published in: Nat Immunol
November 2009

Thymic positive selection is based on the interactions of T cell antigen receptors (TCRs) with self peptide-major histocompatibility complex (MHC) ligands, but the identity of selecting peptides for MHC class II-restricted TCRs and the functional consequences of this peptide specificity are not clear. Here we identify several endogenous self peptides that positively selected the MHC class II-restricted 5C.C7 TCR. The most potent of these also enhanced mature T cell activation, which supports the hypothesis that one function of positive selection is to produce T cells that can use particular self peptide-MHC complexes for activation and/or homeostasis. We also show that inhibiting the microRNA miR-181a resulted in maturation of T cells that overtly reacted toward these erstwhile positively selecting peptides. Therefore, miR-181a helps to guarantee the clonal deletion of particular moderate-affinity clones by modulating the TCR signaling threshold of thymocytes.

Duke Scholars

Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

November 2009

Volume

10

Issue

11

Start / End Page

1162 / 1169

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Peptides
  • MicroRNAs
  • Mice, Knockout
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Histocompatibility Antigens Class II
 

Citation

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Ebert, P. J. R., Jiang, S., Xie, J., Li, Q.-J., & Davis, M. M. (2009). An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol, 10(11), 1162–1169. https://doi.org/10.1038/ni.1797
Ebert, Peter J. R., Shan Jiang, Jianming Xie, Qi-Jing Li, and Mark M. Davis. “An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.Nat Immunol 10, no. 11 (November 2009): 1162–69. https://doi.org/10.1038/ni.1797.
Ebert, Peter J. R., et al. “An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.Nat Immunol, vol. 10, no. 11, Nov. 2009, pp. 1162–69. Pubmed, doi:10.1038/ni.1797.

Published In

Nat Immunol

DOI

EISSN

1529-2916

Publication Date

November 2009

Volume

10

Issue

11

Start / End Page

1162 / 1169

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Peptides
  • MicroRNAs
  • Mice, Knockout
  • Mice
  • Lymphocyte Activation
  • Immunology
  • Histocompatibility Antigens Class II