Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.
Publication
, Journal Article
Swaroop, A; Chew, EY; Rickman, CB; Abecasis, GR
Published in: Annu Rev Genomics Hum Genet
2009
Aging-associated neurodegenerative diseases significantly influence the quality of life of affected individuals. Genetic approaches, combined with genomic technology, have provided powerful insights into common late-onset diseases, such as age-related macular degeneration (AMD). Here, we discuss current findings on the genetics of AMD to highlight areas of rapid progress and new challenges. We also attempt to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis.
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Published In
Annu Rev Genomics Hum Genet
DOI
EISSN
1545-293X
Publication Date
2009
Volume
10
Start / End Page
19 / 43
Location
United States
Related Subject Headings
- Macular Degeneration
- Life Style
- Humans
- Genetics & Heredity
- Genetic Predisposition to Disease
- Eye
- Disease Models, Animal
- Animals
- Age of Onset
- 3105 Genetics
Citation
APA
Chicago
ICMJE
MLA
NLM
Swaroop, A., Chew, E. Y., Rickman, C. B., & Abecasis, G. R. (2009). Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet, 10, 19–43. https://doi.org/10.1146/annurev.genom.9.081307.164350
Swaroop, Anand, Emily Y. Chew, Catherine Bowes Rickman, and Gonçalo R. Abecasis. “Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.” Annu Rev Genomics Hum Genet 10 (2009): 19–43. https://doi.org/10.1146/annurev.genom.9.081307.164350.
Swaroop A, Chew EY, Rickman CB, Abecasis GR. Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet. 2009;10:19–43.
Swaroop, Anand, et al. “Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.” Annu Rev Genomics Hum Genet, vol. 10, 2009, pp. 19–43. Pubmed, doi:10.1146/annurev.genom.9.081307.164350.
Swaroop A, Chew EY, Rickman CB, Abecasis GR. Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet. 2009;10:19–43.
Published In
Annu Rev Genomics Hum Genet
DOI
EISSN
1545-293X
Publication Date
2009
Volume
10
Start / End Page
19 / 43
Location
United States
Related Subject Headings
- Macular Degeneration
- Life Style
- Humans
- Genetics & Heredity
- Genetic Predisposition to Disease
- Eye
- Disease Models, Animal
- Animals
- Age of Onset
- 3105 Genetics