Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration.

Journal Article (Review)

Aging-associated neurodegenerative diseases significantly influence the quality of life of affected individuals. Genetic approaches, combined with genomic technology, have provided powerful insights into common late-onset diseases, such as age-related macular degeneration (AMD). Here, we discuss current findings on the genetics of AMD to highlight areas of rapid progress and new challenges. We also attempt to integrate available genetic and biochemical data with cellular pathways involved in aging to formulate an integrated model of AMD pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Swaroop, A; Chew, EY; Rickman, CB; Abecasis, GR

Published Date

  • 2009

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 19 - 43

PubMed ID

  • 19405847

Electronic International Standard Serial Number (EISSN)

  • 1545-293X

Digital Object Identifier (DOI)

  • 10.1146/annurev.genom.9.081307.164350

Language

  • eng

Conference Location

  • United States