Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.

Journal Article (Journal Article)

We compared the relative toxicities of standard concentrations of two magnetic resonance imaging (MRI) contrast agents, ionic gadolinium diethylenetriaminepentacetic acid (DTPA) and low-osmolar gadolinium-1, 4, 7 tris (carboxymethyl)-10-(2'-hydroxypropyl)-1, 4, 7, 10 tetra-azacyclododecane (HP-DO3A) with that of the conventional radiographic contrast medium meglumine diatrizoate, when extravasated into the deep dermal tissues of laboratory rats. Gadolinium-DTPA caused moderate necrosis, hemorrhage, and edema which was not statistically different than meglumine diatrizoate. In contrast, gadolinium HP-DO3A was significantly less toxic than meglumine diatrizoate. Additional experience will be needed in order to determine whether these laboratory results will be clinically relevant in humans.

Full Text

Duke Authors

Cited Authors

  • Cohan, RH; Leder, RA; Herzberg, AJ; Hedlund, LW; Wheeler, CT; Beam, CA; Nadel, SN; Dunnick, NR

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 224 - 226

PubMed ID

  • 2055727

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-199103000-00005


  • eng

Conference Location

  • United States