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Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.

Publication ,  Journal Article
Cohan, RH; Leder, RA; Herzberg, AJ; Hedlund, LW; Wheeler, CT; Beam, CA; Nadel, SN; Dunnick, NR
Published in: Invest Radiol
March 1991

We compared the relative toxicities of standard concentrations of two magnetic resonance imaging (MRI) contrast agents, ionic gadolinium diethylenetriaminepentacetic acid (DTPA) and low-osmolar gadolinium-1, 4, 7 tris (carboxymethyl)-10-(2'-hydroxypropyl)-1, 4, 7, 10 tetra-azacyclododecane (HP-DO3A) with that of the conventional radiographic contrast medium meglumine diatrizoate, when extravasated into the deep dermal tissues of laboratory rats. Gadolinium-DTPA caused moderate necrosis, hemorrhage, and edema which was not statistically different than meglumine diatrizoate. In contrast, gadolinium HP-DO3A was significantly less toxic than meglumine diatrizoate. Additional experience will be needed in order to determine whether these laboratory results will be clinically relevant in humans.

Duke Scholars

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

March 1991

Volume

26

Issue

3

Start / End Page

224 / 226

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pentetic Acid
  • Osmolar Concentration
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Heterocyclic Compounds
  • Gadolinium DTPA
 

Citation

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Cohan, R. H., Leder, R. A., Herzberg, A. J., Hedlund, L. W., Wheeler, C. T., Beam, C. A., … Dunnick, N. R. (1991). Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat. Invest Radiol, 26(3), 224–226. https://doi.org/10.1097/00004424-199103000-00005
Cohan, R. H., R. A. Leder, A. J. Herzberg, L. W. Hedlund, C. T. Wheeler, C. A. Beam, S. N. Nadel, and N. R. Dunnick. “Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.Invest Radiol 26, no. 3 (March 1991): 224–26. https://doi.org/10.1097/00004424-199103000-00005.
Cohan RH, Leder RA, Herzberg AJ, Hedlund LW, Wheeler CT, Beam CA, et al. Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat. Invest Radiol. 1991 Mar;26(3):224–6.
Cohan, R. H., et al. “Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat.Invest Radiol, vol. 26, no. 3, Mar. 1991, pp. 224–26. Pubmed, doi:10.1097/00004424-199103000-00005.
Cohan RH, Leder RA, Herzberg AJ, Hedlund LW, Wheeler CT, Beam CA, Nadel SN, Dunnick NR. Extravascular toxicity of two magnetic resonance contrast agents. Preliminary experience in the rat. Invest Radiol. 1991 Mar;26(3):224–226.

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

March 1991

Volume

26

Issue

3

Start / End Page

224 / 226

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pentetic Acid
  • Osmolar Concentration
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Heterocyclic Compounds
  • Gadolinium DTPA