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Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.

Publication ,  Journal Article
Bishop, BL; Duncan, MJ; Song, J; Li, G; Zaas, D; Abraham, SN
Published in: Nat Med
May 2007

The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular E. coli.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

May 2007

Volume

13

Issue

5

Start / End Page

625 / 630

Location

United States

Related Subject Headings

  • Urothelium
  • Urinary Tract Infections
  • Urinary Bladder
  • Mice
  • Immunology
  • Humans
  • Exocytosis
  • Escherichia coli Infections
  • Escherichia coli
  • Cyclic AMP
 

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Bishop, B. L., Duncan, M. J., Song, J., Li, G., Zaas, D., & Abraham, S. N. (2007). Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med, 13(5), 625–630. https://doi.org/10.1038/nm1572
Bishop, Brian L., Mathew J. Duncan, Jeongmin Song, Guojie Li, David Zaas, and Soman N. Abraham. “Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.Nat Med 13, no. 5 (May 2007): 625–30. https://doi.org/10.1038/nm1572.
Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med. 2007 May;13(5):625–30.
Bishop, Brian L., et al. “Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.Nat Med, vol. 13, no. 5, May 2007, pp. 625–30. Pubmed, doi:10.1038/nm1572.
Bishop BL, Duncan MJ, Song J, Li G, Zaas D, Abraham SN. Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. Nat Med. 2007 May;13(5):625–630.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

May 2007

Volume

13

Issue

5

Start / End Page

625 / 630

Location

United States

Related Subject Headings

  • Urothelium
  • Urinary Tract Infections
  • Urinary Bladder
  • Mice
  • Immunology
  • Humans
  • Exocytosis
  • Escherichia coli Infections
  • Escherichia coli
  • Cyclic AMP