Skip to main content

Delayed magnetic resonance hepatic imaging with gadolinium-DTPA.

Publication ,  Journal Article
Nelson, RC; Umpierrez, ME; Chezmar, JL; Bernardino, ME
Published in: Invest Radiol
July 1988

Magnetic resonance imaging of the liver was performed on 11 rabbits (3-5 kg) before and at 4, 5 and 6 hours after the intravenous administration of 0.3 mM/kg Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) to determine if hepatocytes exhibit delayed excretion of Gd-DTPA, similar to the delayed hepatic excretion of iodinated contrast agents. Imaging was performed at 0.5 Tesla in the axial plane using a spin echo sequence of TR/TE, 250/20 milliseconds. Precontrast and postcontrast intensity changes for liver and muscle were standardized and compared over time. The average percent of postcontrast enhancement for liver and muscle, respectively was: 30.6 +/- 9.5% and 17.3 +/- 17.0% immediately postcontrast; 9.7 +/- 13.6% and 1.6 +/- 13.8% at 4 hours; 9.6 +/- 7.8% and 4.3 +/- 13.2% at 5 hours; and 11.0 +/- 7.8% and 4.1 +/- 11.7% at 6 hours. We conclude that there is not significant hepatocyte excretion of Gd-DTPA at 4 to 6 hours postcontrast injection in rabbits and that this may not be an advantageous paramagnetic contrast strategy for focal hepatic lesion detection.

Duke Scholars

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

July 1988

Volume

23

Issue

7

Start / End Page

509 / 511

Location

United States

Related Subject Headings

  • Time Factors
  • Rabbits
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Muscles
  • Magnetic Resonance Imaging
  • Liver
  • Image Enhancement
  • Gadolinium DTPA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nelson, R. C., Umpierrez, M. E., Chezmar, J. L., & Bernardino, M. E. (1988). Delayed magnetic resonance hepatic imaging with gadolinium-DTPA. Invest Radiol, 23(7), 509–511. https://doi.org/10.1097/00004424-198807000-00005
Nelson, R. C., M. E. Umpierrez, J. L. Chezmar, and M. E. Bernardino. “Delayed magnetic resonance hepatic imaging with gadolinium-DTPA.Invest Radiol 23, no. 7 (July 1988): 509–11. https://doi.org/10.1097/00004424-198807000-00005.
Nelson RC, Umpierrez ME, Chezmar JL, Bernardino ME. Delayed magnetic resonance hepatic imaging with gadolinium-DTPA. Invest Radiol. 1988 Jul;23(7):509–11.
Nelson, R. C., et al. “Delayed magnetic resonance hepatic imaging with gadolinium-DTPA.Invest Radiol, vol. 23, no. 7, July 1988, pp. 509–11. Pubmed, doi:10.1097/00004424-198807000-00005.
Nelson RC, Umpierrez ME, Chezmar JL, Bernardino ME. Delayed magnetic resonance hepatic imaging with gadolinium-DTPA. Invest Radiol. 1988 Jul;23(7):509–511.

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

July 1988

Volume

23

Issue

7

Start / End Page

509 / 511

Location

United States

Related Subject Headings

  • Time Factors
  • Rabbits
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Muscles
  • Magnetic Resonance Imaging
  • Liver
  • Image Enhancement
  • Gadolinium DTPA