Delayed magnetic resonance hepatic imaging with gadolinium-DTPA.

Published

Journal Article

Magnetic resonance imaging of the liver was performed on 11 rabbits (3-5 kg) before and at 4, 5 and 6 hours after the intravenous administration of 0.3 mM/kg Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) to determine if hepatocytes exhibit delayed excretion of Gd-DTPA, similar to the delayed hepatic excretion of iodinated contrast agents. Imaging was performed at 0.5 Tesla in the axial plane using a spin echo sequence of TR/TE, 250/20 milliseconds. Precontrast and postcontrast intensity changes for liver and muscle were standardized and compared over time. The average percent of postcontrast enhancement for liver and muscle, respectively was: 30.6 +/- 9.5% and 17.3 +/- 17.0% immediately postcontrast; 9.7 +/- 13.6% and 1.6 +/- 13.8% at 4 hours; 9.6 +/- 7.8% and 4.3 +/- 13.2% at 5 hours; and 11.0 +/- 7.8% and 4.1 +/- 11.7% at 6 hours. We conclude that there is not significant hepatocyte excretion of Gd-DTPA at 4 to 6 hours postcontrast injection in rabbits and that this may not be an advantageous paramagnetic contrast strategy for focal hepatic lesion detection.

Full Text

Duke Authors

Cited Authors

  • Nelson, RC; Umpierrez, ME; Chezmar, JL; Bernardino, ME

Published Date

  • July 1988

Published In

Volume / Issue

  • 23 / 7

Start / End Page

  • 509 - 511

PubMed ID

  • 3170138

Pubmed Central ID

  • 3170138

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-198807000-00005

Language

  • eng

Conference Location

  • United States