Recovery of vestibular function following hair cell destruction by streptomycin.


Journal Article

Can the vestibular periphery of warm-blooded vertebrates recover functionally from severe sensory hair cell loss? Recent findings in birds suggest a mechanism for recovery but in fact no direct functional evidence has been reported. We produced vestibular hair cell lesions using the ototoxic agent streptomycin sulfate (600 mg/kg/day, 8 days, chicks, Gallus domesticus). Compound action potentials of the vestibular nerve were used as a direct measure of peripheral vestibular function. Vestibular thresholds, neural activation latencies and amplitudes were documented. Eight days of drug treatment elevated thresholds significantly (P < 0.001) and eliminated all but remnants of vestibular activity. Virtually complete physiological recovery occurred in all animals studied over a period of 70 days following treatment. Thresholds recovered within two weeks of drug treatment whereas the return of response morphologies including activation latencies and amplitudes required an additional 6-8 weeks.

Full Text

Cited Authors

  • Jones, TA; Nelson, RC

Published Date

  • October 1992

Published In

Volume / Issue

  • 62 / 2

Start / End Page

  • 181 - 186

PubMed ID

  • 1429260

Pubmed Central ID

  • 1429260

Electronic International Standard Serial Number (EISSN)

  • 1878-5891

International Standard Serial Number (ISSN)

  • 0378-5955

Digital Object Identifier (DOI)

  • 10.1016/0378-5955(92)90184-o


  • eng