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Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide.

Publication ,  Journal Article
Small, WC; Nelson, RC; Bernardino, ME
Published in: Magn Reson Imaging
1993

BMS 180549 (previously AMI-227), an ultrasmall superparamagnetic iron particulate agent, was investigated to determine its utility as a contrast agent on T1-weighted, as well as T2-weighted sequences, as a function of route of administration, (intravenous versus selective arterial) and concentration. Twelve farm pigs were divided into three groups of four each by route of administration (intravenous, selective superior mesenteric, or selective hepatic arterial injection). 10 mumol/kg and 20 mumol/kg dosages were given and evaluated both immediately after and 20-24 hr after contrast infusion, using both spin-echo and gradient-echo T1 and T2-weighted sequences. Significant postcontrast liver and spleen enhancement was noted at both concentrations, regardless of route of administration on both T1- and T2-weighted sequences. The earliest postcontrast T1-weighted sequence obtained during the 1-3 min interval following IV administration of high dose (20 mumol/kg) contrast demonstrated an average of +42.8% liver and +249.0% spleen enhancement; 24 hr later this decreased to 0 and 7.2%, respectively. The earliest postcontrast T2-weighted sequence obtained during the 8-17 min interval post high-dose IV contrast showed an average of -75.8% decrease in liver and -28.7% decrease in spleen signal intensity; 24 hr later the magnitude of these changes diminished to -33.1% and +2.5%, respectively. No significant difference was noted in liver or spleen enhancement, regardless of route of contrast administration (intravenous versus intraarterial).

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Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

1993

Volume

11

Issue

5

Start / End Page

645 / 654

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Swine
  • Spleen
  • Oxides
  • Nuclear Medicine & Medical Imaging
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Liver
  • Iron
  • Injections, Intravenous
 

Citation

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Chicago
ICMJE
MLA
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Small, W. C., Nelson, R. C., & Bernardino, M. E. (1993). Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide. Magn Reson Imaging, 11(5), 645–654. https://doi.org/10.1016/0730-725x(93)90006-y
Small, W. C., R. C. Nelson, and M. E. Bernardino. “Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide.Magn Reson Imaging 11, no. 5 (1993): 645–54. https://doi.org/10.1016/0730-725x(93)90006-y.
Small WC, Nelson RC, Bernardino ME. Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide. Magn Reson Imaging. 1993;11(5):645–54.
Small, W. C., et al. “Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide.Magn Reson Imaging, vol. 11, no. 5, 1993, pp. 645–54. Pubmed, doi:10.1016/0730-725x(93)90006-y.
Small WC, Nelson RC, Bernardino ME. Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide. Magn Reson Imaging. 1993;11(5):645–654.
Journal cover image

Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

1993

Volume

11

Issue

5

Start / End Page

645 / 654

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Swine
  • Spleen
  • Oxides
  • Nuclear Medicine & Medical Imaging
  • Magnetite Nanoparticles
  • Magnetic Resonance Imaging
  • Liver
  • Iron
  • Injections, Intravenous