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Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model.

Publication ,  Journal Article
Small, WC; Nelson, RC; Sherbourne, GM; Bernardino, ME
Published in: J Magn Reson Imaging
1994

The enhancement characteristics of the liver and spleen produced by a hepatocyte-specific magnetic resonance imaging agent, an arabinogalactan-coated ultrasmall superparamagnetic iron oxide derivative, BMS 180550, were evaluated. Both heavily T1- and T2-weighted sequences were used. Imaging was performed in the farm pig model, as a function of contrast agent concentration (5, 10, and 20 mumol of iron per kilogram) and delay (immediate, 0.5, 2.5, 5.0, 7.5, and 9.0 hours) after bolus injection of BMS 180550. BMS 180550 provided excellent contrast enhancement characteristics by producing marked positive enhancement with T1-weighted sequences and marked negative enhancement with T2-weighted sequences. The T1-weighted enhancement immediately after contrast agent injection was of greater magnitude in the spleen (329% +/- 83) than in the liver (66% +/- 16). Postcontrast negative enhancement with T2-weighted sequences was largely hepatocyte specific at 5 and 10 mumol/kg but was also seen within the spleen at 20 mumol/kg. The authors discuss the possible mechanisms that produce these changes and conclude that 10 mumol/kg BMS 180550 is near the optimum dose for maximizing the enhancement properties of this agent with all sequences in the farm pig.

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Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1994

Volume

4

Issue

3

Start / End Page

325 / 330

Location

United States

Related Subject Headings

  • Time Factors
  • Swine
  • Spleen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Liver
  • Dose-Response Relationship, Drug
  • Contrast Media
  • Animals
  • 11 Medical and Health Sciences
 

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Small, W. C., Nelson, R. C., Sherbourne, G. M., & Bernardino, M. E. (1994). Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model. J Magn Reson Imaging, 4(3), 325–330. https://doi.org/10.1002/jmri.1880040317
Small, W. C., R. C. Nelson, G. M. Sherbourne, and M. E. Bernardino. “Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model.J Magn Reson Imaging 4, no. 3 (1994): 325–30. https://doi.org/10.1002/jmri.1880040317.
Small WC, Nelson RC, Sherbourne GM, Bernardino ME. Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model. J Magn Reson Imaging. 1994;4(3):325–30.
Small, W. C., et al. “Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model.J Magn Reson Imaging, vol. 4, no. 3, 1994, pp. 325–30. Pubmed, doi:10.1002/jmri.1880040317.
Small WC, Nelson RC, Sherbourne GM, Bernardino ME. Enhancement effects of a hepatocyte receptor-specific MR contrast agent in an animal model. J Magn Reson Imaging. 1994;4(3):325–330.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1994

Volume

4

Issue

3

Start / End Page

325 / 330

Location

United States

Related Subject Headings

  • Time Factors
  • Swine
  • Spleen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Liver
  • Dose-Response Relationship, Drug
  • Contrast Media
  • Animals
  • 11 Medical and Health Sciences