Renal allograft rejection: evaluation by Doppler US and MR imaging.

Journal Article (Journal Article)

A prospective study compared the efficacy of Doppler ultrasonography (US) and magnetic resonance (MR) imaging in evaluating 38 renal allografts, with specific attention to transplant rejection. Forty-three Doppler US and 42 MR examinations were performed and interpreted. Histologic correlation was obtained from 22 biopsy or nephrectomy specimens. Clinical correlation or a response to instituted therapy was used as confirmation in the remaining allografts. Accuracy in identifying cyclosporine toxicity or acute tubular necrosis could not be evaluated because there were few such cases, with concomitant rejection in most. The ability to predict and identify presence or absence of rejection was not affected by different serum creatinine values. Doppler US was significantly superior to MR imaging in identifying allograft rejection, demonstrating a higher sensitivity (95% vs. 70%), specificity (95% vs. 73%), and accuracy (95% vs. 71%). Because of its low cost and accessibility, Doppler US should become the primary modality for renal transplant screening.

Full Text

Duke Authors

Cited Authors

  • Steinberg, HV; Nelson, RC; Murphy, FB; Chezmar, JL; Baumgartner, BR; Delaney, VB; Whelchel, JD; Bernardino, ME

Published Date

  • February 1, 1987

Published In

Volume / Issue

  • 162 / 2

Start / End Page

  • 337 - 342

PubMed ID

  • 3541027

International Standard Serial Number (ISSN)

  • 0033-8419

Digital Object Identifier (DOI)

  • 10.1148/radiology.162.2.3541027


  • eng

Conference Location

  • United States