Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

Journal Article (Journal Article)

Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer's Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFalpha, Il-1beta, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease.

Full Text

Duke Authors

Cited Authors

  • Lynch, JR; Morgan, D; Mance, J; Matthew, WD; Laskowitz, DT

Published Date

  • March 1, 2001

Published In

Volume / Issue

  • 114 / 1-2

Start / End Page

  • 107 - 113

PubMed ID

  • 11240021

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/s0165-5728(00)00459-8


  • eng

Conference Location

  • Netherlands