Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.

Journal Article (Journal Article)

OBJECTIVE: The purpose of this study was to determine if patients receiving statin therapy before coronary artery bypass grafting surgery would have less cognitive dysfunction after cardiopulmonary bypass as a consequence of a diminished inflammatory response. DESIGN: Retrospective observational study of patients undergoing coronary artery bypass grafting surgery. SETTING: Referral center for cardiothoracic surgery at a university hospital. PARTICIPANTS: Four hundred forty patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Thirty-five percent of patients received statins in the preoperative period. Multivariable analysis revealed no effect of preoperative statin therapy on cognitive function (p = 0.67). Post hoc analysis revealed that statin therapy at hospital discharge was associated with less improvement in cognitive performance at 6 weeks after surgery (p = 0.011). No significant differences were found between statin therapy groups in either range or maximum value of any of the cytokines (p > 0.05). CONCLUSIONS: Preoperative statin therapy did not decrease the inflammatory response to cardiopulmonary bypass or the cognitive dysfunction commonly seen after cardiac surgery.

Full Text

Duke Authors

Cited Authors

  • Mathew, JP; Grocott, HP; McCurdy, JR; Ti, LK; Davis, RD; Laskowitz, DT; Podgoreanu, MV; Swaminathan, M; Lynch, J; Stafford-Smith, M; White, WD; Newman, MF

Published Date

  • June 2005

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 294 - 299

PubMed ID

  • 16130053

International Standard Serial Number (ISSN)

  • 1053-0770

Digital Object Identifier (DOI)

  • 10.1053/j.jvca.2005.03.004


  • eng

Conference Location

  • United States