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Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.

Publication ,  Journal Article
Wang, H; Lynch, JR; Song, P; Yang, H-J; Yates, RB; Mace, B; Warner, DS; Guyton, JR; Laskowitz, DT
Published in: Exp Neurol
July 2007

The treatment of traumatic brain injury (TBI) remains limited, and aside from surgical hematoma evacuation, clinical management is largely supportive and directed toward management of cerebral edema and intracranial hypertension. Secondary neuronal injury caused by ischemia and the development of cerebral edema may occur in the subacute phase, with intracranial pressures often peaking in the first several days following injury. Because inflammation contributes significantly to the pathophysiology of cerebral ischemia and endothelial dysfunction underlies the development of cerebral edema, therapeutic strategies that target the post-traumatic inflammatory cascade and reduce endothelial dysfunction hold enormous potential to improve clinical outcomes after TBI. Statins inhibit inflammation by suppressing inflammatory cytokine release, and by interfering with multiple steps of leukocyte recruitment and migration into the CNS. In this study, we demonstrate that treatment with atorvastatin and simvastatin markedly reduced functional neurological deficits after traumatic brain injury in mice. These effects were accompanied by histological reduction in degenerating hippocampal neurons and suppression of inflammatory cytokine mRNA expression in brain parenchyma. Furthermore, statin treatment improved cerebral hemodynamics following head injury. Thus, the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury.

Duke Scholars

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Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

July 2007

Volume

206

Issue

1

Start / End Page

59 / 69

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Simvastatin
  • Recovery of Function
  • RNA, Messenger
  • Pyrroles
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Mice, Inbred C57BL
  • Mice
 

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APA
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ICMJE
MLA
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Wang, H., Lynch, J. R., Song, P., Yang, H.-J., Yates, R. B., Mace, B., … Laskowitz, D. T. (2007). Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol, 206(1), 59–69. https://doi.org/10.1016/j.expneurol.2007.03.031
Wang, Haichen, John R. Lynch, Pingping Song, Hyuk-Jun Yang, Robert B. Yates, Brian Mace, David S. Warner, John R. Guyton, and Daniel T. Laskowitz. “Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.Exp Neurol 206, no. 1 (July 2007): 59–69. https://doi.org/10.1016/j.expneurol.2007.03.031.
Wang, Haichen, et al. “Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.Exp Neurol, vol. 206, no. 1, July 2007, pp. 59–69. Pubmed, doi:10.1016/j.expneurol.2007.03.031.
Wang H, Lynch JR, Song P, Yang H-J, Yates RB, Mace B, Warner DS, Guyton JR, Laskowitz DT. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol. 2007 Jul;206(1):59–69.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

July 2007

Volume

206

Issue

1

Start / End Page

59 / 69

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Simvastatin
  • Recovery of Function
  • RNA, Messenger
  • Pyrroles
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Degeneration
  • Mice, Inbred C57BL
  • Mice