Serum markers of cerebral ischemia.


Journal Article

Rapid diagnosis and management of stroke patients is becoming increasingly important with the emergence of new interventional strategies for acute cerebral ischemia. A biochemical surrogate of cerebral ischemia, rapidly detectable in the serum before radiological diagnosis, might have clinical utility in the setting of acute stroke, high-risk cardiovascular procedures, and subarachnoid hemorrhage. Such a marker might also aid in the neurological prognosis of anoxic brain injury. Several serum markers have been evaluated in acute cerebral ischemia. These include neuronal enzymes such as neuron-specific enolase; markers of glial injury and activation, such as protein S100beta; and mediators of inflammation, such as interleukin-6. The clinical and preclinical data supporting the use of these biochemical surrogates of cerebral ischemia are reviewed.

Full Text

Duke Authors

Cited Authors

  • Laskowitz, DT; Grocott, H; Hsia, A; Copeland, KR

Published Date

  • July 1998

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 234 - 241

PubMed ID

  • 17895090

Pubmed Central ID

  • 17895090

International Standard Serial Number (ISSN)

  • 1052-3057


  • eng

Conference Location

  • United States