Skip to main content
Journal cover image

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

Publication ,  Journal Article
Ivancevich, NM; Pinton, GF; Nicoletto, HA; Bennett, E; Laskowitz, DT; Smith, SW
Published in: Ultrasound Med Biol
September 2008

Contrast-enhanced (CE) transcranial ultrasound (US) and reconstructed 3-D transcranial ultrasound have shown advantages over traditional methods in a variety of cerebrovascular diseases. We present the results from a novel ultrasound technique, namely real-time 3-D contrast-enhanced transcranial ultrasound. Using real-time 3-D (RT3D) ultrasound and microbubble contrast agent, we scanned 17 healthy volunteers via a single temporal window and nine via the suboccipital window and report our detection rates for the major cerebral vessels. In 71% of subjects, both of our observers identified the ipsilateral circle of Willis from the temporal window, and in 59% we imaged the entire circle of Willis. From the suboccipital window, both observers detected the entire vertebrobasilar circulation in 22% of subjects, and in 44%, the basilar artery. After performing phase aberration correction on one subject, we were able to increase the diagnostic value of the scan, detecting a vessel not present in the uncorrected scan. These preliminary results suggest that RT3D CE transcranial US and RT3D CE transcranial US with phase aberration correction have the potential to greatly impact the field of neurosonology.

Duke Scholars

Published In

Ultrasound Med Biol

DOI

ISSN

0301-5629

Publication Date

September 2008

Volume

34

Issue

9

Start / End Page

1387 / 1395

Location

England

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Microbubbles
  • Male
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Humans
  • Female
  • Contrast Media
  • Computer Systems
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ivancevich, N. M., Pinton, G. F., Nicoletto, H. A., Bennett, E., Laskowitz, D. T., & Smith, S. W. (2008). Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction. Ultrasound Med Biol, 34(9), 1387–1395. https://doi.org/10.1016/j.ultrasmedbio.2008.01.015
Ivancevich, Nikolas M., Gianmarco F. Pinton, Heather A. Nicoletto, Ellen Bennett, Daniel T. Laskowitz, and Stephen W. Smith. “Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.Ultrasound Med Biol 34, no. 9 (September 2008): 1387–95. https://doi.org/10.1016/j.ultrasmedbio.2008.01.015.
Ivancevich NM, Pinton GF, Nicoletto HA, Bennett E, Laskowitz DT, Smith SW. Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction. Ultrasound Med Biol. 2008 Sep;34(9):1387–95.
Ivancevich, Nikolas M., et al. “Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.Ultrasound Med Biol, vol. 34, no. 9, Sept. 2008, pp. 1387–95. Pubmed, doi:10.1016/j.ultrasmedbio.2008.01.015.
Ivancevich NM, Pinton GF, Nicoletto HA, Bennett E, Laskowitz DT, Smith SW. Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction. Ultrasound Med Biol. 2008 Sep;34(9):1387–1395.
Journal cover image

Published In

Ultrasound Med Biol

DOI

ISSN

0301-5629

Publication Date

September 2008

Volume

34

Issue

9

Start / End Page

1387 / 1395

Location

England

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Microbubbles
  • Male
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Humans
  • Female
  • Contrast Media
  • Computer Systems