Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

Journal Article (Journal Article)

We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

Full Text

Duke Authors

Cited Authors

  • Kasper, AC; Moon, EJ; Hu, X; Park, Y; Wooten, CM; Kim, H; Yang, W; Dewhirst, MW; Hong, J

Published Date

  • July 15, 2009

Published In

Volume / Issue

  • 19 / 14

Start / End Page

  • 3783 - 3786

PubMed ID

  • 19423348

Pubmed Central ID

  • PMC2709708

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.04.071


  • eng

Conference Location

  • England