Amphetamine trials and tribulations.
Publication
, Journal Article
Goldstein, LB
Published in: Stroke
March 2009
BACKGROUND: Laboratory experiments conducted since the 1940s show that amphetamine combined with task-relevant experience improves postbrain injury behavioral outcomes. Several small clinical trials evaluated the approach as a means of improving poststroke recovery. RESULTS: In laboratory studies, the effect of amphetamine on recovery depends on the location and extent of brain injury, the dosing and timing of amphetamine, and the type, intensity, and timing of concomitant behavioral training. The small clinical trials conducted to date vary considerably in critical aspects of their designs and are largely negative. CONCLUSIONS: The question of whether d-amphetamine combined with physiotherapy is of any clinical value remains unanswered.
Duke Scholars
Published In
Stroke
DOI
EISSN
1524-4628
Publication Date
March 2009
Volume
40
Issue
3 Suppl
Start / End Page
S133 / S135
Location
United States
Related Subject Headings
- Time Factors
- Stroke
- Rats
- Randomized Controlled Trials as Topic
- Neurology & Neurosurgery
- Humans
- Dose-Response Relationship, Drug
- Disease Models, Animal
- Central Nervous System Stimulants
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Goldstein, L. B. (2009). Amphetamine trials and tribulations. Stroke, 40(3 Suppl), S133–S135. https://doi.org/10.1161/STROKEAHA.108.533703
Goldstein, Larry B. “Amphetamine trials and tribulations.” Stroke 40, no. 3 Suppl (March 2009): S133–35. https://doi.org/10.1161/STROKEAHA.108.533703.
Goldstein LB. Amphetamine trials and tribulations. Stroke. 2009 Mar;40(3 Suppl):S133–5.
Goldstein, Larry B. “Amphetamine trials and tribulations.” Stroke, vol. 40, no. 3 Suppl, Mar. 2009, pp. S133–35. Pubmed, doi:10.1161/STROKEAHA.108.533703.
Goldstein LB. Amphetamine trials and tribulations. Stroke. 2009 Mar;40(3 Suppl):S133–S135.
Published In
Stroke
DOI
EISSN
1524-4628
Publication Date
March 2009
Volume
40
Issue
3 Suppl
Start / End Page
S133 / S135
Location
United States
Related Subject Headings
- Time Factors
- Stroke
- Rats
- Randomized Controlled Trials as Topic
- Neurology & Neurosurgery
- Humans
- Dose-Response Relationship, Drug
- Disease Models, Animal
- Central Nervous System Stimulants
- Animals