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Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.

Publication ,  Journal Article
Phillips-Bute, B; Mathew, JP; Blumenthal, JA; Morris, RW; Podgoreanu, MV; Smith, M; Stafford-Smith, M; Grocott, HP; Schwinn, DA; Newman, MF ...
Published in: Psychosom Med
November 2008

OBJECTIVE: To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery. METHODS: A total of 427 coronary artery bypass graft (CABG) patients were genotyped for two polymorphisms and assessed for depressive symptoms at three time points, in accordance with the Center for Epidemiological Studies-Depression (CES-D): preoperative baseline; 6 months postoperative; and 1 year postoperative. Logistic regression was used to assess the association between depressive symptoms (CES-D = >16), genotype differences, and cardiac events. Because MAOA-uVNTR is sex-linked, males and females were analyzed separately for this polymorphism; sexes were combined for the 5HTTLPR analysis. RESULTS: Depressed patients were more likely than nondepressed patients to have a new cardiac event within 2 years of surgery (p < .0001); depressed patients who carry the long (L) allele of the 5HTTLPR polymorphism were more likely than the short/short (S/S carriers to have an event (p = .0002). Genetic associations with 6-month and 1-year postoperative depressive symptoms do not survive adjustment for baseline depressive symptoms. CONCLUSIONS: A serotonin-related gene polymorphism--5HTTLPR--was associated with adverse cardiac events post CABG, in combination with depressive symptoms. Because depressed patients with the L allele of the 5HTTLPR polymorphism were more likely to have an event compared with the S/S carriers, combining genetic and psychiatric profiling may prove useful in identifying patients at the highest risk for adverse outcomes post CABG.

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Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

November 2008

Volume

70

Issue

9

Start / End Page

953 / 959

Location

United States

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Risk Factors
  • Psychiatry
  • Promoter Regions, Genetic
  • Postoperative Complications
  • Mutagenesis, Insertional
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Middle Aged
  • Male
 

Citation

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Phillips-Bute, B., Mathew, J. P., Blumenthal, J. A., Morris, R. W., Podgoreanu, M. V., Smith, M., … Perioperative Genetics and Safety Outcomes Investigative Team, . (2008). Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med, 70(9), 953–959. https://doi.org/10.1097/PSY.0b013e318187aee6
Phillips-Bute, Barbara, Joseph P. Mathew, James A. Blumenthal, Richard W. Morris, Mihai V. Podgoreanu, Michael Smith, Mark Stafford-Smith, et al. “Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.Psychosom Med 70, no. 9 (November 2008): 953–59. https://doi.org/10.1097/PSY.0b013e318187aee6.
Phillips-Bute B, Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, et al. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med. 2008 Nov;70(9):953–9.
Phillips-Bute, Barbara, et al. “Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.Psychosom Med, vol. 70, no. 9, Nov. 2008, pp. 953–59. Pubmed, doi:10.1097/PSY.0b013e318187aee6.
Phillips-Bute B, Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, Stafford-Smith M, Grocott HP, Schwinn DA, Newman MF, Perioperative Genetics and Safety Outcomes Investigative Team. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med. 2008 Nov;70(9):953–959.

Published In

Psychosom Med

DOI

EISSN

1534-7796

Publication Date

November 2008

Volume

70

Issue

9

Start / End Page

953 / 959

Location

United States

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Risk Factors
  • Psychiatry
  • Promoter Regions, Genetic
  • Postoperative Complications
  • Mutagenesis, Insertional
  • Monoamine Oxidase
  • Minisatellite Repeats
  • Middle Aged
  • Male