HIV vaccines: brief review and discussion of future directions.


Journal Article (Review)

A major barrier to the design of a successful HIV vaccine is virus diversity,which is particularly apparent in the envelope glycoprotein, the target of neutralizing antibodies. An antibody generated to one envelope glycoprotein may not recognize an isolate bearing a different envelope glycoprotein. Thus, single-envelope glycoprotein vaccines have protected against homologous but not necessarily against heterologous challenge. Antigenic diversity has been addressed in the design of vaccines for other pathogens by the preparation of polyvalent vaccines. The poliovirus vaccine, for example, comprises three serotypes of poliovirus, a feature that was essential in providing full protection against polio infection. Similarly, the authors propose that overcoming HIV diversity is likely to require the administration of a cocktail of envelope glycoprotein antigens. Delivery of such an array of envelope glycoproteins will elicit a broad immune response that is potentially capable of recognizing the diverse population of HIV-1 isolates. This article reviews data relevant to the development of cocktail vaccines which have been designed to elicit a wide range of envelope glycoprotein-specific B- and T-cell responses.

Full Text

Duke Authors

Cited Authors

  • Slobod, KS; Bonsignori, M; Brown, SA; Zhan, X; Stambas, J; Hurwitz, JL

Published Date

  • June 2005

Published In

Volume / Issue

  • 4 / 3

Start / End Page

  • 305 - 313

PubMed ID

  • 16026246

Pubmed Central ID

  • 16026246

Electronic International Standard Serial Number (EISSN)

  • 1744-8395

Digital Object Identifier (DOI)

  • 10.1586/14760584.4.3.305


  • eng

Conference Location

  • England