HIV vaccine rationale, design and testing.


Journal Article (Review)

A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope molecules from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design. For example, the poliovirus vaccine includes three serotypes of poliovirus, and Pneumovax presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific B-cell and T-cell responses, are reviewed.

Full Text

Duke Authors

Cited Authors

  • Slobod, KS; Coleclough, C; Bonsignori, M; Brown, SA; Zhan, X; Surman, S; Zirkel, A; Jones, BG; Sealy, RE; Stambas, J; Brown, B; Lockey, TD; Freiden, PJ; Doherty, PC; Blanchard, JL; Martin, LN; Hurwitz, JL

Published Date

  • April 2005

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 107 - 112

PubMed ID

  • 15853717

Pubmed Central ID

  • 15853717

International Standard Serial Number (ISSN)

  • 1570-162X

Digital Object Identifier (DOI)

  • 10.2174/1570162053506928


  • eng

Conference Location

  • Netherlands