Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection.
Journal Article (Journal Article)
Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.
Full Text
Duke Authors
Cited Authors
- Fadel, SA; Cowell, LG; Cao, S; Ozaki, DA; Kepler, TB; Steeber, DA; Sarzotti, M
Published Date
- February 2006
Published In
Volume / Issue
- 18 / 2
Start / End Page
- 249 - 257
PubMed ID
- 16418189
International Standard Serial Number (ISSN)
- 0953-8178
Digital Object Identifier (DOI)
- 10.1093/intimm/dxh360
Language
- eng
Conference Location
- England