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Protein S-nitrosylation in health and disease: a current perspective.

Publication ,  Journal Article
Foster, MW; Hess, DT; Stamler, JS
Published in: Trends Mol Med
September 2009

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human diseases. Here we review recent findings that implicate S-nitrosylation in cardiovascular, pulmonary, musculoskeletal and neurological (dys)function, as well as in cancer. The emerging picture shows that, in many cases, pathophysiology correlates with hypo- or hyper-S-nitrosylation of specific protein targets rather than a general cellular insult due to loss of or enhanced nitric oxide synthase activity. In addition, it is increasingly evident that dysregulated S-nitrosylation can not only result from alterations in the expression, compartmentalization and/or activity of nitric oxide synthases, but can also reflect a contribution from denitrosylases, including prominently the S-nitrosoglutathione (GSNO)-metabolizing enzyme GSNO reductase. Finally, because exogenous mediators of protein S-nitrosylation or denitrosylation can substantially affect the development or progression of disease, potential therapeutic agents that modulate S-nitrosylation could well have broad clinical utility.

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Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

September 2009

Volume

15

Issue

9

Start / End Page

391 / 404

Location

England

Related Subject Headings

  • Signal Transduction
  • Proteins
  • Nitrosation
  • Nitric Oxide
  • Nitrates
  • Immunology
  • Humans
  • Health
  • Disease
  • Animals
 

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Foster, M. W., Hess, D. T., & Stamler, J. S. (2009). Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med, 15(9), 391–404. https://doi.org/10.1016/j.molmed.2009.06.007
Foster, Matthew W., Douglas T. Hess, and Jonathan S. Stamler. “Protein S-nitrosylation in health and disease: a current perspective.Trends Mol Med 15, no. 9 (September 2009): 391–404. https://doi.org/10.1016/j.molmed.2009.06.007.
Foster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med. 2009 Sep;15(9):391–404.
Foster, Matthew W., et al. “Protein S-nitrosylation in health and disease: a current perspective.Trends Mol Med, vol. 15, no. 9, Sept. 2009, pp. 391–404. Pubmed, doi:10.1016/j.molmed.2009.06.007.
Foster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med. 2009 Sep;15(9):391–404.
Journal cover image

Published In

Trends Mol Med

DOI

EISSN

1471-499X

Publication Date

September 2009

Volume

15

Issue

9

Start / End Page

391 / 404

Location

England

Related Subject Headings

  • Signal Transduction
  • Proteins
  • Nitrosation
  • Nitric Oxide
  • Nitrates
  • Immunology
  • Humans
  • Health
  • Disease
  • Animals