Protein S-nitrosylation in health and disease: a current perspective.

Published

Journal Article (Review)

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human diseases. Here we review recent findings that implicate S-nitrosylation in cardiovascular, pulmonary, musculoskeletal and neurological (dys)function, as well as in cancer. The emerging picture shows that, in many cases, pathophysiology correlates with hypo- or hyper-S-nitrosylation of specific protein targets rather than a general cellular insult due to loss of or enhanced nitric oxide synthase activity. In addition, it is increasingly evident that dysregulated S-nitrosylation can not only result from alterations in the expression, compartmentalization and/or activity of nitric oxide synthases, but can also reflect a contribution from denitrosylases, including prominently the S-nitrosoglutathione (GSNO)-metabolizing enzyme GSNO reductase. Finally, because exogenous mediators of protein S-nitrosylation or denitrosylation can substantially affect the development or progression of disease, potential therapeutic agents that modulate S-nitrosylation could well have broad clinical utility.

Full Text

Duke Authors

Cited Authors

  • Foster, MW; Hess, DT; Stamler, JS

Published Date

  • September 2009

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 391 - 404

PubMed ID

  • 19726230

Pubmed Central ID

  • 19726230

Electronic International Standard Serial Number (EISSN)

  • 1471-499X

International Standard Serial Number (ISSN)

  • 1471-4914

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2009.06.007

Language

  • eng