Protein S deficiency: imaging findings.


Journal Article

Protein S deficiency is an autosomal-dominant inherited disorder of coagulation associated with spontaneous and recurrent venous thrombosis. Approximately 5% of patients with deep venous thrombosis of the lower extremities who are less than 45 years old have a deficiency of protein S. Patients frequently have spontaneous and recurrent deep venous thrombosis and pulmonary embolism during young adulthood. Thrombosis occurs less commonly in the splanchnic and cerebral veins. Arterial thrombosis is rare but is seen in the cerebral circulation. Radiologists should include protein S deficiency in the differential diagnosis of unexplained thrombosis in young patients. This pictorial essay illustrates the range of imaging findings encountered in patients with this disorder.

Full Text

Duke Authors

Cited Authors

  • Earls, JP; McAdams, HP; Colon, E; Jelinek, JS

Published Date

  • December 1993

Published In

Volume / Issue

  • 161 / 6

Start / End Page

  • 1283 - 1287

PubMed ID

  • 8249743

Pubmed Central ID

  • 8249743

International Standard Serial Number (ISSN)

  • 0361-803X

Digital Object Identifier (DOI)

  • 10.2214/ajr.161.6.8249743


  • eng

Conference Location

  • United States