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Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings.

Publication ,  Journal Article
Malchow, SC; McAdams, HP; Palmer, SM; Tapson, VF; Putman, CE
Published in: Acad Radiol
October 1998

RATIONALE AND OBJECTIVES: The authors evaluated the effect of the native emphysematous lung on graft function after single lung transplantation. MATERIALS AND METHODS: Thirty-two patients who underwent single lung transplantation were examined with radiography preoperatively for degree of emphysema and postoperatively for hyperexpansion of the native lung. All patients underwent ventilation-perfusion scanning before transplantation and ventilation scanning after transplantation. Pulmonary function tests and measurement of arterial partial pressure of oxygen were also measured before and after surgery. The postoperative course was graded on a subjective scale. RESULTS: Hyperexpansion of the native lung was seen in 16 of the 32 patients in the postoperative period. On the basis of serial measurements of forced expiratory volume in 1 minute, these patients fared poorly in the postoperative period compared with patients without hyperexpansion. Pulmonary blood flow to the native lung, as measured with perfusion scintigraphy, paradoxically increased in 11 patients after transplantation. Nine of these 11 patients demonstrated hyperinflation of the native lung, suggesting that graft compression adversely affects blood flow to the transplanted lung. CONCLUSION: Hyperexpansion of the native lung after single lung transplantation for emphysema may have a deleterious effect on graft function and possibly on clinical outcome.

Duke Scholars

Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

October 1998

Volume

5

Issue

10

Start / End Page

688 / 693

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Pulmonary Emphysema
  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung Transplantation
  • Lung
  • Humans
 

Citation

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ICMJE
MLA
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Malchow, S. C., McAdams, H. P., Palmer, S. M., Tapson, V. F., & Putman, C. E. (1998). Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings. Acad Radiol, 5(10), 688–693. https://doi.org/10.1016/s1076-6332(98)80563-1
Malchow, S. C., H. P. McAdams, S. M. Palmer, V. F. Tapson, and C. E. Putman. “Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings.Acad Radiol 5, no. 10 (October 1998): 688–93. https://doi.org/10.1016/s1076-6332(98)80563-1.
Malchow SC, McAdams HP, Palmer SM, Tapson VF, Putman CE. Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings. Acad Radiol. 1998 Oct;5(10):688–93.
Malchow, S. C., et al. “Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings.Acad Radiol, vol. 5, no. 10, Oct. 1998, pp. 688–93. Pubmed, doi:10.1016/s1076-6332(98)80563-1.
Malchow SC, McAdams HP, Palmer SM, Tapson VF, Putman CE. Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings. Acad Radiol. 1998 Oct;5(10):688–693.
Journal cover image

Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

October 1998

Volume

5

Issue

10

Start / End Page

688 / 693

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Pulmonary Emphysema
  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Lung Transplantation
  • Lung
  • Humans