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Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings.

Publication ,  Journal Article
Collins, J; Kazerooni, EA; Lacomis, J; McAdams, HP; Leung, AN; Shiau, M; Semenkovich, J; Love, RB
Published in: Radiology
July 2002

PURPOSE: To determine the frequency, clinical characteristics, and radiologic findings of bronchogenic carcinoma in patients surviving more than 1 month after lung transplantation. MATERIALS AND METHODS: The study population was composed of 2,168 consecutive patients at seven lung transplantation centers who survived longer than 1 month after lung transplantation. Medical records, chest radiographs, and computed tomographic (CT) scans obtained at the time of diagnosis and prior images when available were reviewed for various items of information and imaging features. RESULTS: Twenty-four (1%) of the 2,168 patients, all with single-lung transplants, developed cancer in the native lung. Eighteen patients had emphysema, and six had pulmonary fibrosis. The frequencies of cancer in patients with emphysema and fibrosis were 2% (18 of 859 patients) and 4% (six of 147 patients), respectively. Twelve (50%) of their 24 cancers were detected at chest radiography. Fourteen (58%) patients had clinical symptoms. Twenty-one (88%) of the 24 patients had one (n = 11) or more (n = 10) nodules, and nine (38%) had one (n = 8) or more (n = 1) masses visible on CT scans. Nodules and masses were visible on 12 (50%) and seven (29%) of 24 chest radiographs, respectively. Eleven (48%) of 23 cancers for which prior chest radiographs were available were seen retrospectively on prior chest radiographs. CONCLUSION: Bronchogenic carcinoma develops in the native lung of transplant recipients with emphysema and pulmonary fibrosis with frequencies of 2% and 4%, respectively. The carcinomas most commonly manifest as a pulmonary nodule or mass on chest radiographs, with more nodules seen on CT scans.

Duke Scholars

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

July 2002

Volume

224

Issue

1

Start / End Page

131 / 138

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiography, Thoracic
  • Pulmonary Fibrosis
  • Pulmonary Emphysema
  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Lung Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
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Collins, J., Kazerooni, E. A., Lacomis, J., McAdams, H. P., Leung, A. N., Shiau, M., … Love, R. B. (2002). Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology, 224(1), 131–138. https://doi.org/10.1148/radiol.2241011189
Collins, Jannette, Ella A. Kazerooni, Joan Lacomis, H Page McAdams, Ann N. Leung, Maria Shiau, Janice Semenkovich, and Robert B. Love. “Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings.Radiology 224, no. 1 (July 2002): 131–38. https://doi.org/10.1148/radiol.2241011189.
Collins J, Kazerooni EA, Lacomis J, McAdams HP, Leung AN, Shiau M, et al. Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology. 2002 Jul;224(1):131–8.
Collins, Jannette, et al. “Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings.Radiology, vol. 224, no. 1, July 2002, pp. 131–38. Pubmed, doi:10.1148/radiol.2241011189.
Collins J, Kazerooni EA, Lacomis J, McAdams HP, Leung AN, Shiau M, Semenkovich J, Love RB. Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. Radiology. 2002 Jul;224(1):131–138.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

July 2002

Volume

224

Issue

1

Start / End Page

131 / 138

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiography, Thoracic
  • Pulmonary Fibrosis
  • Pulmonary Emphysema
  • Postoperative Complications
  • Nuclear Medicine & Medical Imaging
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Lung Transplantation