Glow discharge plasma deposition of tetraethylene glycol dimethyl ether for fouling-resistant biomaterial surfaces.


Journal Article

The glow discharge plasma deposition (GDPD) of tetraethylene glycol dimethyl ether is introduced as a novel method for obtaining surfaces that are resistant to protein adsorption and cellular attachment. Analysis of films by x-ray photoelectron spectroscopy and several biological assays indicate the formation of a fouling-resistant, PEO-like surface on several substrata (e.g., glass, polytetrafluoroethylene, polyethylene). Adsorption of 125I-radiolabelled proteins (fibrinogen, albumin and IgG) from buffer and plasma was very low (typically less than 20 ng/cm2) when compared to the untreated substrata, which exhibited much higher levels of protein adsorption. Not all coated substrata adsorbed equal amounts of protein (e.g., coated glass samples typically adsorbed more protein than coated polyethylene or coated polytetrafluoroethylene samples), suggesting that the substratum used may affect the amount of protein adsorbed. Measurement of dynamic platelet adhesion, using epifluorescent video microscopy, and endothelial cell attachment further demonstrates the short-term nonadhesiveness of these surfaces.

Full Text

Cited Authors

  • López, GP; Ratner, BD; Tidwell, CD; Haycox, CL; Rapoza, RJ; Horbett, TA

Published Date

  • April 1, 1992

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 415 - 439

PubMed ID

  • 1601898

Pubmed Central ID

  • 1601898

Electronic International Standard Serial Number (EISSN)

  • 1097-4636

International Standard Serial Number (ISSN)

  • 0021-9304

Digital Object Identifier (DOI)

  • 10.1002/jbm.820260402


  • eng