Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.

Journal Article (Journal Article)

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.

Full Text

Duke Authors

Cited Authors

  • Yamaoka, LH; Westbrook, CA; Speer, MC; Gilchrist, JM; Jabs, EW; Schweins, EG; Stajich, JM; Gaskell, PC; Roses, AD; Pericak-Vance, MA

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 4 / 5-6

Start / End Page

  • 471 - 475

PubMed ID

  • 7881291

Pubmed Central ID

  • 7881291

International Standard Serial Number (ISSN)

  • 0960-8966

Digital Object Identifier (DOI)

  • 10.1016/0960-8966(94)90086-8


  • eng

Conference Location

  • England