Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.
Publication
, Journal Article
Yamaoka, LH; Westbrook, CA; Speer, MC; Gilchrist, JM; Jabs, EW; Schweins, EG; Stajich, JM; Gaskell, PC; Roses, AD; Pericak-Vance, MA
Published in: Neuromuscul Disord
1994
Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.
Duke Scholars
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Published In
Neuromuscul Disord
DOI
ISSN
0960-8966
Publication Date
1994
Volume
4
Issue
5-6
Start / End Page
471 / 475
Location
England
Related Subject Headings
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Muscular Dystrophies
- Lod Score
- Humans
- Haplotypes
- Genotype
- Genetic Linkage
- DNA, Satellite
- Chromosome Mapping
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NLM
Yamaoka, L. H., Westbrook, C. A., Speer, M. C., Gilchrist, J. M., Jabs, E. W., Schweins, E. G., … Pericak-Vance, M. A. (1994). Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscul Disord, 4(5–6), 471–475. https://doi.org/10.1016/0960-8966(94)90086-8
Yamaoka, L. H., C. A. Westbrook, M. C. Speer, J. M. Gilchrist, E. W. Jabs, E. G. Schweins, J. M. Stajich, P. C. Gaskell, A. D. Roses, and M. A. Pericak-Vance. “Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.” Neuromuscul Disord 4, no. 5–6 (1994): 471–75. https://doi.org/10.1016/0960-8966(94)90086-8.
Yamaoka LH, Westbrook CA, Speer MC, Gilchrist JM, Jabs EW, Schweins EG, et al. Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscul Disord. 1994;4(5–6):471–5.
Yamaoka, L. H., et al. “Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.” Neuromuscul Disord, vol. 4, no. 5–6, 1994, pp. 471–75. Pubmed, doi:10.1016/0960-8966(94)90086-8.
Yamaoka LH, Westbrook CA, Speer MC, Gilchrist JM, Jabs EW, Schweins EG, Stajich JM, Gaskell PC, Roses AD, Pericak-Vance MA. Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscul Disord. 1994;4(5–6):471–475.
Published In
Neuromuscul Disord
DOI
ISSN
0960-8966
Publication Date
1994
Volume
4
Issue
5-6
Start / End Page
471 / 475
Location
England
Related Subject Headings
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Muscular Dystrophies
- Lod Score
- Humans
- Haplotypes
- Genotype
- Genetic Linkage
- DNA, Satellite
- Chromosome Mapping